Histochemical demonstration of enhanced glutathione content in enzyme-altered islands induced by carcinogens in rat liver
Deml, E.; Oesterle, D.
Cancer Research 40(2): 490-491
1980
ISSN/ISBN: 0008-5472 PMID: 6101309 Document Number: 159304
The presence of glutathione was demonstrated histochemically in livers of rats treated with diethylnitrosamine or N-nitrosomorpholine. Glutathione content was markedly elevated in adenosine triphosphatase-deficient, gamma-glutamyltranspeptidase-positive hyperplastic cell islands. This finding may partly explain the increased resistance of hyperplastic cells to cytotoxic actions of hepatocarcinogens.
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