Influence of ranitidine on antipyrine metabolism
Staiger, C.; Simon, B.; de Vries, J.; Kather, H.; Walter, E.
Zeitschrift für Gastroenterologie 18(12): 601-604
1980
ISSN/ISBN: 0044-2771 PMID: 6116365 Document Number: 159091
Antipyrine kinetics were determined in 6 healthy volunteers before and after the end of a 1 week treatment period of ranitidine 150 mg twice a day. The mean antipyrine half-life (h) was before 12.6 +/- 4.6 h and after ranitidine treatment 12.0 +/- 2.6 h. Antipyrine clearance (ml/min) and volume of distribution (1) were not altered following ranitidine administration. The results suggest that ranitidine has no influence on antipyrine-metabolism in healthy volunteers.
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