Enhanced antipyrine metabolism in cigarette smokers in Indian population
Uppal, R.; Garg, S.K.; Sharma, P.R.; Nair, C.R.; Chaudhury, R.R.
International Journal of Clinical Pharmacology Therapy and Toxicology 18(6): 269-271
1980
ISSN/ISBN: 0174-4879 PMID: 7450928 Document Number: 154808
A single oral dose of 18 mg/kg body weight of antipyrine was administered to 10 chronic cigarette smokers and to 9 appropriate control healthy volunteers. Plasma antipyrine half-life (t1/2.beta.) was shortened significantly (P < 0.05) in cigarette smokers as compared to the non-smokers control group. Antipyrine was cleared from the blood faster in cigarette smokers, with a mean increase in metabolic clearance rate from 0.637 ml/min per kg in nonsmokers to 0.831 ml/min per kg in cigarette smokers. Concern as to enhanced metabolism of other drugs is probably warranted in cigarette smokers.