Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones
Davies, P.J.; Davies, D.R.; Levitzki, A.; Maxfield, F.R.; Milhaud, P.; Willingham, M.C.; Pastan, I.H.
Nature 283(5743): 162-167
1980
ISSN/ISBN: 0028-0836 PMID: 6153122 Document Number: 158733
The receptor-mediated endocytosis of alpha 2-macroglobulin can be inhibited by a diverse group of chemical compounds all of which share the property of being inhibitors of one form of cellular transglutaminase. The present results strongly suggest that protein cross-linking may be essential for receptor-mediated endocytosis of some protein and polypeptide hormones.