Natural history of recurrent molar pregnancy
Federschneider, J.M.; Goldstein, D.P.; Berkowitz, R.S.; Marean, A.R.; Bernstein, M.R.
Obstetrics and Gynecology 55(4): 457-459
1980
ISSN/ISBN: 0029-7844 PMID: 7366903 Document Number: 158722
Seven patients with recurrent molar pregnancy were managed at the New England Trophoblastic Disease Center (NETDC) between July 1965 and December 1978. Recurrent molar pregnancy was associated with a worsening histology and an increased incidence of proliferative trophoblastic sequelae in the successive episodes of hydatidiform mole. While none of the initial 7 patients with molar pregnancy required any further treatment after evacuation, 5 of the 7 patients needed chemotherapy to achieve complete sustained remission of the recurrent episodes of hydatidiform mole. None of the patients with recurrent hydatidiform mole had normal viable pregnancies after 2 or more consecutive molar gestations. The literature regarding recurrent molar pregnancy is reviewed in the context of the authors' current observations.