Micellar properties and surface activity of some bolaform drugs in aqueous solution
Attwood, D.; Natarajan, R.
Journal of Pharmacy and Pharmacology 32(7): 460-462
1980
ISSN/ISBN: 0022-3573 PMID: 6105180 Document Number: 157498
The micellar properties of a series of dicationic drugs with structures resembling those of the bolaform electrolytes were examined using light scattering, surface tension and conductivity techniques. The compounds investigated included demecarium bromide, ambenonium chloride, dequalinium acetate, distigmine bromide and chlorhexidine acetate. Demecarium and dequalinium formed micelles at critical concentrations of 9 .times. 10-3 and 4 .times. 10-3 mol/kg, respectively. No significant association of chlorhexidine acetate could be detected, contrary to previous reports.