Kinetics of the cell proliferation of murine mammary adenocarcinoma under the influence of methylcobalamine
Golenko, O.D.; Arsenian, F.G.; Miasishcheva, N.V.; Sof'ina, Z.P.
Biulleten' Eksperimental'noi Biologii i Meditsiny 89(2): 185-187
1980
ISSN/ISBN: 0365-9615 PMID: 7370419 Document Number: 157227
The mechanism of the stimulant effect of methylcobalamine on the growth of mouse adenocarcinoma 755 was studied. More rapid growth of adenocarcinoma 755 under the cobalamine coentzyme effect is consequent on an increased proliferative pool with the stable parameters of the mitotic cycle and minimal death of tumour cells. Apparently, inhibition of DNA synthesis in the greater S-phase cell subpopulation potentiated the antitumour effect of methotrexate combined with methylcobalamine.