4'-Epi-doxorubicin and hyperthermia in a murine mammary carcinoma: influence of the dose and fractionation
Cividalli, A.; Danesi, D.T.; Altavista, P.; Bonanni, M.; Persiani, D.; Segre, L.; Cruciani, G.
Anticancer Research 15(3): 739-743
1995
ISSN/ISBN: 0250-7005 PMID: 7645951 Document Number: 444438
Our aim was to analyse the dose-response rate of 4'-epi-doxorubicin (EP) alone and of EP combined with hyperthermia (HT) treatments in tumor-beating mice. A spontaneous mammary carcinoma, transplanted into the tight foot of female hybrid (C3H/RI times DBA/2J) mice, was used. EP (from 5 to 30 mg/kg) was administered i.p. and local HT (45-60 minutes at 42 or 43 degree C) was carried out. Mice were treated with EP and/or HT in 1, 2 or 3 doses at 8 day intervals; in the case of 3 HT treatments EP was administered before the first or before each HT session (same EP total dose). When EP was given alone, in 1 or 2 fractions, results showed a clear dose-response relationship: tumor growth delay depended on the total dose only. Combining different EP single doses and 1 HT treatment (43 degree C), an additive effect and perhaps a synergistic effect at the highest doses was observed. Among all tested combinations, the best results were observed combining 3 HT with only 1 EP treatment.