Variation of urinary acid glycosaminoglycan and collagen metabolite excretion with disease activity in generalized scleroderma
Blumenkrantz, N.; Asboe-Hansen, G.
Acta Dermato-Venereologica 60(1): 39-43
1980
ISSN/ISBN: 0001-5555 PMID: 6153832 Document Number: 157196
Follow-up of patients with generalized scleroderma improving during treatment with collagen biosynthesis inhibitors showed a decrease towards normalization of the elevated urinary values for acid glycosaminoglycans and collagen catabolites. The determinations supply objective evidence of the disease activity as well as of the efficacy of treatment. In the control group, relatively high urinary values for the two macromolecules were found in the second decade of life in comparison with older age groups.