Urinary excretion of pantothenic acid as a measurement of nutritional requirements
Pietrzik, K.; Hesse, C.H.; Zur Wiesch, E.S.; Hötzel, D.
International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift für Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition 45(2): 153-162
1975
ISSN/ISBN: 0300-9831 PMID: 1165163 Document Number: 84883
Several groups of male Wistar-Rats were fed for 15 month with a purified diet containing different amounts of pantothenic acid. The groups received 150, 100, 25 and 0% pantothenic acid of the requirement respectively. A further group was fed without pantothenic acid in the diet but administered with the antagonist omega-methyl-pantothenic acid. The excretion of pantothenic acid in the urine was measured at different times, and a groups specific level of excretion could be established for the different groups. Differences to the controls were highly significant in the test groups after 2-18 weeks. Studies of this type were conducted in order to obtain basic informations for later experiments in human beings.