The role of the pathologist in the management of gastrointestinal stromal tumors (GIST)
Bouzourene, H.
Revue Medicale Suisse 5(211): 1505-1508
2009
ISSN/ISBN: 1660-9379 PMID: 19694360 Document Number: 15591
Considerable progress was realized these last years in the understanding of the molecular mechanisms and the treatment of the GIST. Their diagnosis remains based on the morphology and immunohistochemistry. The evaluation of GIST prognosis was till know difficult to establish but a new histopronostic classification currently used allows a better therapeutic approach. The search for KIT and PDGFRA mutations is recommended to adapt a targeted therapy by KIT inhibitors. The pathologist plays a crucial role in the management of the GIST because it is on him that is based the diagnosis, the evaluation of the prognosis and the treatment (surgery and kit inhibitors).
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