Beta 2-microglobulin in human renal cortical tissue
Popelier, G.; Sion, H.
Acta Clinica Belgica 35(Suppl): 40-47
1980
ISSN/ISBN: 1784-3286 PMID: 6157291 Document Number: 154885
The total content of .beta.2-microglobulin (.beta.2.mu.) in human renal cortex has a mean value of 3 .+-. 1 .mu.g/g and can be found as well in the hydrosoluble protein fraction as in the solubilized one with a ratio of 0.8. The tissues with pronounced nephroangiosclerosis contain less .beta.2.mu. (2.1 .+-. 0.5 .mu.g/g) and those with chronic pyelonephritis a significant higher content (3.8 .+-. 1.2 .mu.g/g). The ratio between hydrosoluble and the solubilized fractions is different with a value of 0.75 in the tissues with chronic pyelonephritis and 1.2 in those with nephroangiosclerosis. When the results are expressed/mg of total protein, only the values in the tissues with chronic pyelonephritis (98 .+-. 33 ng/mgP) differ statistically from the normal tissue (59 .+-. 22 ng/mgP) and from the tissues with nephroangiosclerosis (44 .+-. 14 ng/mgP). Leukocytic infiltrations or saturation by a deficient turnover of the .beta.2.mu. may explain the difference.