Chronic infantile lactate acidosis

Papanastasiou, D.; Lehnert, W.; Schuchmann, L.; Hommes, F.A.

Helvetica Paediatrica Acta 35(3): 253-260

1980


ISSN/ISBN: 0018-022X
PMID: 7410111
Document Number: 154350
A baby with congenital lactic acidosis is described. The blood levels of lactic acid and alanine as well as the excretion of these compounds in the urine were largely elevated. Clinically the illness presented with vomiting, poor feeding, areflexia, muscular hypotonia and hepatomegaly. The baby died at the age of three months. The pyruvate dehydrogenase complex in cultured fibroblasts showed an activity of 14% of normal values.

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