The effect of pulmonary inflation and deflation upon the circulation
Thompson, S.A.
Journal of Thoracic Surgery 17(3): 323-334
1948
ISSN/ISBN: 0096-5588 PMID: 18865476 Document Number: 15337
We have described a method of observing the effect of mechanical artificial respiration upon the circulation when the heart is no longer heating. This is alone by the introduction of tracer substances into the vascular system of animals immediately after death and by observing the movement of these tracers while the lungs are inflated and deflated. The tracers used were radioactive sodium, fluorescein, and oxygen. By this method we have shown that the mechanical inflation and deflation of the lungs produces all actual movement of the 1)100(1 column and that the blood can he circulated in this way over the entire body without the benefit of any heart action whatever. The clinical. application of this knowledge in resuscitation is of twofold importance; (1) the oxygenated blood in the pulmonary capillaries would be transported to the brain and, heart; (2) intravaseuian medications would also be transported to the vital centers of the body. The value of heparin in resuscitation has been demonstrated. Those mechanical resuscitators employing alternating positive and negative pressures were by Inc more efficient in circulating the blood than were those machines employing only positive or negative pressures alone.
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