Location of immunoglobulins in the skin of cattle and sheep
Lloyd, D.H.; Jenkinson, D.M.; Mabon, R.M.
Research in Veterinary Science 26(1): 47-52
1979
ISSN/ISBN: 0034-5288 PMID: 382317 Document Number: 153260
The pattern of distribution of immunoglobulins (Ig) found within the skin of cattle and sheep was the same in both species. IgA was detected mainly in the sweat gland duct and in the intercellular spaces of the living epidermis. IgG was also located at the latter site but was found in greater amounts throughout the dermis and in the endothelium of the blood vessels. IgM was primarily located at the basement membrane of the epithelial structures, in the hair papilla and in the walls of the blood vessels. Lower concentrations of IgM were also detected in the upper dermis.