Effect of a typhoid lipopolysaccharide on the primary and secondary immunological response to ram erythrocytes
Pershin, S.B.; Tumanian, M.A.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 12: 33-36
1979
ISSN/ISBN: 0372-9311 PMID: 574698 Document Number: 151722
The effect of typhoid bacterial lipopolysaccharide (LPS) on the primary and secondary response to sheep red blood cells was studied. LPS, injected simultaneously with the antigen, stimulated the synthesis of IgM and IgG, as well as the production of rosette-forming cells. When injected on days 2 and 3 after the secondary immunization, LPS induced the maximum stimulation of IgM, IgG and rosette-forming cells, while the injection of LPS prior to immunization induced immunosuppression which particularly affected IgG and rosette-forming cells.