Changes in the sorption of the antigens of the causative agent of typhoid on erythrocytes in the dynamic immune response
Kravtsov, E.G.; Flerova, N.K.; Sukhoroslova, L.I.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 1987(3): 75-78
1987
ISSN/ISBN: 0372-9311 PMID: 2438866 Document Number: 295669
The study of the adsorption capacity of erythrocytes in 4 strains of mice was made. According to the results of the determination of the background capacity of erythrocytes, the strains of mice, opposite with respect to the sorption of S. typhi Vi- and O-antigens, were selected. After the immunization of these mice with the killed culture of S. typhi, the process of the sorption of the antigen on erythrocytes showed a characteristic kinetics. The course of immune response was characterized by specific changes in the adsorption capacity of erythrocytes in all strains of mice: the increase of this capacity on week 1 was followed by its sharp drop on weeks 3-4 and its subsequent restoration to the initial level by weeks 7-8. The non-specific stimulation of the host had no essential influence on the kinetics of the fixation of S. typhi antigens on erythrocytes. Experiments with the passive immunization of the animals revealed that different receptors take part in the process of the sorption of Vi-antigen on erythrocytes, some of these receptors being related to antibodies.