Influence of allopurinol on the half-life of tolbutamide and rifamycin-SV in blood of healthy volunteers
Gentile, S.; Porcellini, M.; Foglia, F.; Loguercio, C.; Coltorti, M.
Bollettino della Societa Italiana di Biologia Sperimentale 55(4): 345-348
1979
ISSN/ISBN: 0037-8771 PMID: 552849 Document Number: 151011
The influence of treatment with allopurinol (5 mg/kg/die for 15 days) on T/2 of tolbutamide and rifomycin-SV intravenously administered, has been studied in 10 healthy volunteers. We have observed reduction of T/2 of tolbutamide and, on the contrary, prolongation of T/2 of rifamycin-SV. Tolbutamide behaviour was unexpected, considering that other Authors had previously found inhibition of metabolic degradation of other drugs metabolized by the microsomal enzymes. We conclude that data concerning the influence of a drug (in our case, allopurinol) on the metabolism of another drug cannot always authorize general deduction and previsions regarding the metabolic interferences on the pharmacokinetics of other substances.