Oxidative damage to the erythrocyte induced by sodium chlorite, in vitro
Heffernan, W.P.; Guion, C.; Bull, R.J.
Journal of Environmental Pathology and Toxicology 2(6): 1501-1510
1979
ISSN/ISBN: 0146-4779 PMID: 528854 Document Number: 150868
The ability of sodium chlorite , in vitro, was examined and compared to that of nitrite. The oxidative damage resulting from chlorite is fundamentally different from that of nitrite. Nitrite is slightly more potent as a Hb oxidant, while chlorite appears to be less specific in its oxidation of cellular constituents. Unlike nitrite, chlorite depleted erythrocyte glutathione, which was accompanied by an increase in hydrogen peroxide generation. Chlorite also produced substantial changes in erythrocyte membrane morphology. These effects of chlorite are characteristic of compounds that produce oxidant-induced hemolytic anemia in vivo.