Early scanning electron microscopy changes of the surface of the leaflets of orthotopic transplanted glyceraldehyd-conditioned conus-pulmonalis xenografts. An experimental study in dogs
Geroulanos, S.; Gossler, W.; Walpoth, B.; Turina, M.; Senning, A.
Helvetica Chirurgica Acta 46(1-2): 91-98
1979
ISSN/ISBN: 0018-0181 PMID: 468587 Document Number: 147578
The surface of the leaflets of orthotopic transplanted glutaraldehyd-conditioned conus-pulmonalis xenografts show when analysed by a scanning microscope the following constant changes. Within seconds the surface of the leaflets is covered by a grainy layer of proteins followed by fibrin threads. Cellular elements of the blood--like platelets, white blood cells, macrophages and microthrombi--are incorporated in the fibrin network. This leads, after several weeks to a fibrous layer especially over the stiff parts of the valve. No endothelium was seen even after 6 months.