A review of the renin-angiotensin system: historical and methodological perspectives
Moore, A.F.
Methods and Findings in Experimental and Clinical Pharmacology 1(1): 23-44
1979
ISSN/ISBN: 0379-0355 PMID: 399652 Document Number: 147318
It is apparent that early studies of the renin-AII system utilized measurement of blood pressure and organ bath techniques. More recent methods of electrophoresis, RIA and binding studies are continuing to add to our knowledge. Future studies will involve receptor isolation and understanding of the post-receptor mechanism of transduction of the AII response. With the recent advances in our knowledge of peptide hormone-receptor interaction, particularly new findings that peptide hormones can enter the cell, it is apparent that intracellular actions of AII will provide a new field of discovery.