Endothelial antibodies in renal transplantation
Paul, L.C.; van Es, L.A.; Claas, F.H.; Kalff, M.W.
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association 16: 431-436
1979
ISSN/ISBN: 0071-2736 PMID: 398516 Document Number: 147074
Sera of 97 consecutive transplant recipients were studied for the presence of antibodies directed against their renal allografts. A highly significant correlation (p less than 0.001) was found between irreversible rejection and donor-specific endothelial antibodies (EAb). EAb reacted not only with the endothelium of peritubular capillaries and venules, but also with glomeruli. Absorption of EAb to platelets, B- or T-lymphocytes did not remove its EAb activity or its cytotoxicity for monocytes. Furthermore, it was shown with a panel of randomly chosen donor kidneys, that EAb are directed against a polymorphic system of endothelial-monocyte antigens, which is unrelated to HLA-A, -B, -C or -D.