Lidocaine pharmacokinetics and substantiation of the new method of its administration in myocardial infarct
Piotrovskiĭ, V.K.; Smirnova, E.B.; Riabokon', O.S.; Mazur, N.A.; Metelitsa, V.I.
Kardiologiia 19(7): 23-27
1979
ISSN/ISBN: 0022-9040 PMID: 470315 Document Number: 146321
Lidocain pharmacokinetics was studied in 12 patients with acute myocardial infarction (males and females from 40 to 90 years of age with obvious disorders of hepatic and kidney function or severe hemodynamic disorders). In ten of them the main pharmacokinetic parameters were determined; the average value of lidocain clearance was 0.45 1/min. The optimum rate of continuous drip infusion was calculated (1.35 mg/min). It is shown that the existing method of lidocain administration by the "initial dose + infusion" schedule is unsatisfactory from the pharmacokinetic standpoint. Recommendations are given for the choice of the optimum concentrations of lidocain solution used in different rates of continuous infusion.