Inhibition of in vitro cytotoxic responses by BCG-induced macrophage-like suppressor cells. II. Suppression occurs at the level of a "helper" T cell
Klimpel, G.R.; Okada, M.; Henney, C.S.
Journal of Immunology 123(1): 350-357
1979
ISSN/ISBN: 0022-1767 PMID: 156233 Document Number: 144233
The ability of adherent, macrophage-like spleen cells from BCG-infected C57BL/6 mice to suppress primary cytotoxic responses to alloantigen in vitro was studied. Suppression was dependent on a viable suppressor cell, for heating (56.degree. C 30 min) and glutaraldehyde treatment (0.1%, 2 min) ablated the suppressive action. Membrane preparations were not suppressive. Suppression was reversible and independent of the suppressor cell's Fc receptor sites.
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