Correlation between suppression of B cell anti-hapten response and generation of cytotoxic T cells induced by hapten-labelled syngeneic lymphocytes
Ramos, T.; Möller, E.
Scandinavian Journal of Immunology 13(2): 119-125
1981
ISSN/ISBN: 0300-9475 PMID: 6453419 Document Number: 172222
The correlation between B cell antibody response suppression and generation of cytotoxic T cells induced by hapten (FITC -FITC 0.5 or SC-FITC 0.05 could be demonstrated after in vitro restimulation with similarly haptenated cells. Cells from primed mice gave a cytotoxic response after 3 days in culture, whereas primary responses were only observed on day 5. Immunization was evident as an increased specific lysis at low effector/target ratios. No direct cytotoxicity could be detected in spleen cells from immune animals. Comparison between kinetics of in vivo development of specific antibody suppression and induction of cytotoxic cells detectable after in vitro boosting revealed no correlation between the 2 phenomena.