Primary cutaneous Cryptococcosis during therapy with methotrexate and adalimumab
Wilson, M.L.; Sewell, L.D.; Mowad, C.M.
Journal of Drugs in Dermatology Jdd 7(1): 53-54
2008
ISSN/ISBN: 1545-9616 PMID: 18246698 Document Number: 14335
Primary cutaneous infection with Cryptococcus neoformans is uncommon, but can occur following an inoculation injury to the skin. Tumor necrosis factor-alpha (TNF-alpha) is important in the immune response to Cryptococcus, and patients taking inhibitors of TNF-alpha may have increased susceptibility to cryptococcal infection. We report a case of primary cutaneous cryptococcosis in a patient taking adalimumab, methotrexate, and hydroxychloroquine for rheumatoid arthritis.
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