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Studies on PGBx, a polymeric derivative of prostaglandin B1: I. Synthesis and purification of PGBx

Polis, B.D.; Kwong, S.; Polis, E.; Nelson, G.; Shmukler, H.W.

Physiological Chemistry and Physics 11(2): 109-123

1979

ISSN/ISBN: 0031-9325
PMID: 482383
Document Number: 143093
PGBx, a new polymeric derivative of PGB1, restored oxidative phosphorylation to degraded isolated rat liver mitochondria in vitro and reversed the effects of cardiogenic ischemia in monkeys and cerebral ischemia in rabbits. This report describes in detail the synthesis and purification of PGBx via PGB1, starting with azelaic acid. Details of the in vitro mitochondrial assay are also reported. Purified PGBx exhibiting maximal reactivation of mitochondrial phosphorylation has a mean MW of 2350. Yield of PGBx based on azelaic acid is 4% and based on PGB1 is 25%.

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