Recipient conditioning with beagle plasma and beagle liver: prolongation of kidney-graft function without preoperative lymphocytotoxic antibody formation
Harder, F.; Floersheim, G.L.; Jeekel, J.; vd Linden, C.; Mihatsch, M.J.; Rüedi, T.; Tondelli, P.
Helvetica Chirurgica Acta 46(1-2): 219-223
1979
ISSN/ISBN: 0018-0181 PMID: 381255 Document Number: 142065
Donorspecific recipient conditioning in the non-related beagle produces prolonged kidney-graft survival without any postoperative immunosuppression. Besides 2 donor blood injections on days--18 and--11 followed by a 6-day preoperative immunosuppressive pulse (Procarbazine, ATS) donor plasma and a donor liver preparation are equally active. Additional long-term low dose preoperative immunosuppression with azathioprine tends to strengthen the effect. Lymphocytotoxic antibody formation is avoided in the recipient where no whole blood is used.