Biological evaluation of mibolerone in the female Beagle
Sokolowski, J.H.; Geng, S.
American Journal of Veterinary Research 38(9): 1371-1376
1977
ISSN/ISBN: 0002-9645 PMID: 921032 Document Number: 122849
Mibolerone (17- beta -hydroxy-7 alpha -17-dimethyloestr-4-en-3-one) effectively inhibited oestrous activity in immature or mature Beagle bitches given 60 and 200 mu g, respectively, daily for up to 730 days. A dose level of 20 mu g of mibolerone daily was 70% effective on preventing oestrus. Effects of mibolerone included oestrus inhibition, prolongation of the interoestrous interval in bitches given 20 mu g of the mibolerone daily, vaginal discharge, and a dose-related increase in clitoral size. A decrease in posttreatment conception rate was observed only in bitches receiving 20 mu g of mibolerone daily for 730 days. Pups born to bitches conceiving after mibolerone treatment were grossly normal.