The effects of diseases of the liver on serum 25-hydroxyvitamin D and on the serum binding protein for vitamin D and its metabolites
Imawari, M.; Akanuma, Y.; Itakura, H.; Muto, Y.; Kosaka, K.; Goodman, D.S.
Journal of Laboratory and Clinical Medicine 93(1): 171-180
1979
ISSN/ISBN: 0022-2143 PMID: 569678 Document Number: 141907
The effects of liver damage on the serum levels of 25-OH-D and DBP [serum binding protein for vitamin D and its metabolites] were examined in patients with acute hepatitis, chronic hepatitis and cirrhosis. Serum DBP levels were moderately decreased in patients with chronic hepatitis and markedly decreased in patients with early acute hepatitis and cirrhosis. Serum DBP levels in patients with acute hepatitis increased to normal values as the disease improved. Vitamin D2 supplementation did not affect serum DBP levels. Serum DBP levels correlated positively with serum albumin levels and negatively with serum bilirubin levels, both in patients with acute hepatitis and in patients with chronic hepatitis and cirrhosis. Serum DBP levels correlated negatively with serum GOT [glutamic-oxaloacetic transaminase] levels in patients with acute hepatitis. Without vitamin D2 supplementation, serum 25-OH-D levels in patients with chronic hepatitis did not differ from those in normal subjects, but serum 25-OH-D levels in patients with cirrhosis were decreased. Serum 25-OH-D levels correlated positively with serum DBP and albumin levels and negatively with serum bilirubin levels in patients with chronic hepatitis and cirrhosis. On vitamin D2 supplementation, serum 25-OH-D levels were increased in both patients with chronic hepatitis and those with cirrhosis and correlated positively with serum DBP and albumin levels. The serum levels of DBP and 25-OH-D and the response of serum 25-OH-D to vitamin D2 supplementation reflect the functional status of the liver and the severity of the disease.