Long-term evaluation of colchicine in the treatment of scleroderma
Alarcon-Segovia, D.; Ramos-Niembro, F.; Ibanez de Kasep, G.; Alcocer, J.; Tamayo, R.P.
Journal of Rheumatology 6(6): 705-712
1979
ISSN/ISBN: 0315-162X PMID: 529256 Document Number: 141699
Fifteen patients with PSS, 4 with CRST syndrome, and 4 with localized scleroderma have been treated with colchicine at the maximum tolerated individual doses for an average of 39 months (range 19--57). All but 2 of the 19 patients with generalized scleroderma and 3 of those with localized scleroderma improved. Patients who had had scleroderma for less than 5 yr when begun on colchicine, and those who received total doses of colchicine of more than 1,438 mg, scored a significantly higher mean response index than those with longer disease duration, or those who received less colchicine.