Effect of preoperative paromomycin therapy on the course of wound healing after colonic intervention. a prospective blind study
Kugel, E.; Mad, H.; Esch, P.M.
Fortschritte der Medizin 97(32): 1382-1384
1979
ISSN/ISBN: 0015-8178 PMID: 488880 Document Number: 139675
156 patients undersent colorectal surgery during a prospective blind study at the Städt. Krankenhaus München-Harlaching. The study showed that administration of 4,0 g Paromomycin (= Humatin) on each of the two preoperative days combined with mechanical cleansing of the intestine has a beneficial effect. Our test group showed significantly lower incidence of wound complications at the abdominal laparotomies (p less than 0,05; X2) and at the anastomoses (p less than 0,01; X2 than the control group. Anastomic leakage (major leaks) and following septical complications occurred nearly exclusively in our "Not-Humatin-group". The lethality of the entire group was 13,1% (n = 20).