Dynamic hormonal tests in a case of premature ovarian failure
Asch, R.H.; Bryner, J.; Watatani, H.; Mills, T.; Greenblatt, R.B.
Southern Medical Journal 72(1): 72-74
1979
ISSN/ISBN: 0038-4348 PMID: 760224 Document Number: 139588
The case of a patient with premature ovarian failure and a history of polycystic ovarian disease was described. Dynamic gonadal and pituitary tests were done. Ovarian, adrenal, and peripheral veins were catheterized to determine the steroid secretion under HCG stimulation. In vitro studies of the capacity of ovarian steroidogenesis confirmed the refractory nature of the gonad. Lack of gonadal response, both in vivo and in vitro, to stimulation suggests a possible alteration in ovarian sensitivity to gonadotropins as a possible cause of premature menopause.