Alterations of lactate dehydrogenase isoenzymes with subacute adriamycin toxicity
Olson, H.M.; Shannon, C.F.
Cancer Treatment Reports 63(11-12): 2057-2059
1979
ISSN/ISBN: 0361-5960 PMID: 526938 Document Number: 139482
Single doses of Adriamycin (ADR) and isoproterenol in CDF rats produce significant increases in total serum lactate dehydrogenase (LDH) activity, LDH isoenzymes, and LDH-1/LDH-2 ratio. Isoproterenol produced significant increases in LDH-1, LDH-2, and LDH-3 and the LDH-1/LDH-2 ratio; ADR produced significant increases in all isoenzymes, reflecting widespread toxicity, with peak levels of total LDH, LDH isoenzymes, and LDH-1/LDH-2 ratio at 48 hours after injection. While the increased LDH-1/LDH-2 ratio may suggest myocardial leakage with ADR administration, the results are too nonspecific to conclude that the heart is the primary source of serum LDH-1 and LDH-2.