Influence of diazepam on the effect of neuromuscular blocking agents
Sharma, K.K.; Sharma, U.C.
Journal of Pharmacy and Pharmacology 30(1): 64
1978
ISSN/ISBN: 0022-3573 PMID: 22734 Document Number: 139047
The sciatic nerve gastrocnemius muscle preparations were made in 10 dogs of either sex. The sciatic nerve was ligated and a shielded silver electrode was placed on the peripheral portion. Diazepam in the commercially available solution significantly reversed the neuromuscular blockade produced by a non-depolarizing agent like succinylcholine. It appears that diazepam in commercially available solution and at high doses has an effect somewhat like neostigmine as it antagonized the neuromuscular blockade produced by gallamine and prolonged that produced by succinylcholine.