The influence of beta-blocking agents on the kinin system in rat plasma
Szurska, G.; Kleinrok, Z.
Journal of Pharmacy and Pharmacology 30(5): 323-324
1978
ISSN/ISBN: 0022-3573 PMID: 26753 Document Number: 126126
The hypotensive effect of .beta.-blocking agents has been reported in man and in normotensive or spontaneously hypertensive animals, but the mechanism is not clear. An effect on the renin-angiotensin system was postulated and the inhibition of the renin secretion was suggested to be responsible. The influence of .beta.-blocking drugs on the kinin system was studied by estimating in the rat the concentration of kininogen in vivo and the activation of prekallikrein in vitro. The .beta.-blocking drugs used were: propranolol, alprenolol, sotalol, Ko 1366-bunitrolol, practolol and pindolol. Phentolamin, an .alpha.-receptor blocking agent was also studied. The activation of the kinin system in rat plasma seems to be a specific effect of .beta.-blocking drugs.