Effect of alpha-blocking agents on the internal anal sphincter muscle
Holschneider, A.M.; Kraeft, H.
Zeitschrift für Kinderchirurgie und Grenzgebiete 30(2): 152-161
1980
ISSN/ISBN: 0044-2909 PMID: 7415557 Document Number: 167697
47 patients with functional chronic constipation associated with an achalasia of the anal sphincter were treated with the alpha blocking agent Phenoxybenzamin. Dosages were used according to the manufacturers' instructions. 29 of the children were completely cured. There was significant improvement in a further 13 children and only 5 patients showed no improvement. Treatment failures were associated with additional severe psychological disturbances for which psycho-therapeutic management was required.