Renal function, insulin secretion, and glucose tolerance in mild streptozotocin diabetes in the dog
Kaneko, J.J.; Mattheeuws, D.; Rottiers, R.P.; Vermeulen, A.
American Journal of Veterinary Research 39(5): 807-809
1978
ISSN/ISBN: 0002-9645 PMID: 153115 Document Number: 138426
A mild, stable diabetes mellitus was induced in dogs, using a small (20 mg/kg of body wt) dose of streptozotocin [an antibiotic and anti-tumor agent derived from Streptomyces achromogenes] in a standard volume of 200 ml infused in 15 min. The stability of the diabetes was evidenced by the results of a standard i.v. glucose-tolerance test, insulin response to the glucose load and urinary glucose excretion. The results of the urinary clearances for urea, creatinine and phosphate indicated minimal renal toxicosis and that the toxicosis was localized to the tubules.