The effect of gastrin on gastric ulceration in pigs after bile duct ligation
Watson, R.G.; Vinik, A.I.; van Hoorn-Hickman, R.; Terblanche, J.
South African Medical Journal 54(24): 1019-1021
1978
ISSN/ISBN: 0256-9574 PMID: 746440 Document Number: 138344
Pigs develop gastric ulceration spontaneously and after bile duct ligation. Despite increased basal acid secretion, serum gastrin levels are not elevated, and a possible 'protective' role of gastrin was proposed. Continuous intravenous infusion of synthetic human gastrin did not protect from gastric ulceration, but was associated with simultaneous duodenal ulceration. Another ulcerogenic mechanism must be invoked.
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