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Oxidation of 4-N- (aniline) -5-methoxy-1,2-dioxybenzene via the mitochondrial respiratory chain

Totpvets, Z.P.

Biokhimiia 43(2): 260-267

1978

ISSN/ISBN: 0320-9725
PMID: 647077
Document Number: 137427
A possibility of efficient oxidation of 4-N-(aniline)-5-methoxy-1,2-dioxybenzene (AMOBQH2) via the mitochondrial respiratory chain is demonstrated. The AMOBQH2 oxidation is accompanied by oxidative phosphorylation of ADP. The site of AMOBQH2 interaction is located in the region of cytochrome b, between rotenone and antimycin block. The bimolecular rate constant of AMOBQH2 oxidation using a steady-state approach is found to be 7.8.10(5) M(-1) S(-1). Differentiation of the two Amobqh2 oxidation pathways (mitochondrial one and that of auto-oxidation) and modelling of the auto-oxidation are carried out. Biochemical estimates of biological activities of AMOBQH2 analogues are discussed and proposed.

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