Nitrosoguanidine mutagenesis during the yeast cell cycle
Carter, B.L.; Dawes, I.W.
Mutation Research 51(2): 289-292
1978
ISSN/ISBN: 0027-5107 PMID: 357963 Document Number: 137261
The distribution of spontaneous erythromycin-resistant mutants as a function of cell-cycle stage was examined in Saccharomyces cerevisiae. The overall frequency of erythromycin-resistant mutants was much lower than NG (nitrosoguanidine)-induced mutagenesis. The level of mutagenesis was the same at all stages of the cell cycle. NG results in enhanced mutation during periods of active DNA synthesis.
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