Calculation of Steel's cell loss factor and of the cellular kinetic parameters for a population with an exponential growth of the cell number and an equal probability of cell death in all phases of the life cycle
Gushchin, V.A.
Tsitologiia 26(12): 1365-1371
1984
ISSN/ISBN: 0041-3771 PMID: 6528360 Document Number: 225637
A method of calculation of parameter m (equal to a doubled probability of birth of cells which did not pass into phase G0 from the mitotic cycle) and of the proliferative pool was shown to be the same for the exponential growth phase of cell population with the equal probability of cell death (lambda = const) at all phases of the life cycle (the Steel model of type E), and for the case "lambda = 0" (the Steel model of type B). The method is proposed for the calculation of parameter lambda and of the Steel cell lose factor phi = lambda/[lambda + [ln 2)/tD)]. It is noted that the value of parameter phi for the type E model can be estimated by the Steel formula: phi congruent to 1-tDpot/tD--where tD is the doubling time of the cell number, and tDpot = tcln 2/ln m. Here tc is the mean mitotic cycle duration.