Transient pseudoleukocytosis caused by cryocrystalglobulinemia
Shah, P.C.; Rao, K.; Noble, V.; Kumaraiah, V.; Patel, A.R.
Archives of Pathology and Laboratory Medicine 102(4): 172-173
1978
ISSN/ISBN: 0003-9985 PMID: 580708 Document Number: 136934
A patient with Sjögren's syndrome and cryoglobulinemia was found to have pseudoleukocytosis when a leukocyte count was performed on an electronic particle counter. This apparent increase in the leukocyte count was found to be caused by spontaneous crystallization of the cryoglobulin. Further studies showed that this phenomenon was transient. Disappearance of the spontaneous crystal formation without a change in the level of cryoglobulin suggests the possibility of an interaction between the cryoglobulin and a plasma component. Factors affecting spontaneous crystallization of cryoglobulins and the laboratory as well as the clinical implications of pseudoleukocytosis are discussed.