Cefazolin concentrations in bone and synovial fluid
Schurman, D.J.; Hirshman, H.P.; Kajiyama, G.; Moser, K.; Burton, D.S.
Journal of Bone and Joint Surgery. American Volume 60(3): 359-362
1978
ISSN/ISBN: 0021-9355 PMID: 649639 Document Number: 135318
A single intravenous dose of one gram of cefazolin was administered prophylactically to forty-eight patients undergoing total joint replacement. The serum half-life of the antibiotic was 1.8 hours, the same value found in normal volunteers. The mean concentration in bone during surgery was 5.7 micrograms per gram of bone. The mean concentration in synovial fluid during surgery was 24.4 micrograms per milliliter of fluid.
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