Synovial fluid cartilage metabolism marker concentrations in osteonecrosis of the femoral head compared with osteoarthrosis of the hip
Iwase, T.; Hasegawa, Y.; Ishiguro, N.; Ito, T.; Iwasada, S.; Kitamura, S.; Iwata, H.
Journal of Rheumatology 25(3): 527-531
1998
ISSN/ISBN: 0315-162X PMID: 9517775 Document Number: 486925
Objective. Biochemical aspects of the etiology of articular cartilage degeneration in osteonecrosis of the femoral head have not been investigated extensively. We analyzed biochemical conditions in the hip joint cavity, regarding articular cartilage turnover in osteonecrosis of the femoral head (ONFH). Methods. Cartilage metabolism markers in synovial fluid were measured. Synovial fluid (SF) samples were collected from 19 ONFH cases and 17 control hips with osteoarthrosis (OA). Concentrations of carboxy-terminal type II procollagen peptide (pCOL-II-C), matrix metalloproteinase-3 (MMP-3), and tissue inhibitor of metalloproteinase-1 (TIMP-1) were measured. In addition, concentrations of unsaturated disaccharides of hyaluronic acid (DELTAdi-HA), chondroitin 4-sulfate (DELTAdi-4S), and chondroitin 6-sulfate (DELTAdi-6S) in SF were measured by high performance liquid chromatography. Results. The mean SF concentration of pCOL-II-C was higher on ONFH than in OA. The mean SF MMP-3 level was higher in ONFH than in OA, while the mean SF TIMP-1 level was the same in the 2 groups. The SF concentration of DELTAdi-HA and the DELTAdi-6S/DELTAdi-4S ratio were higher in ONFH than in OA. Conclusion. Higher concentrations of cartilage metabolism markers in ONFH compared with OA SF suggest elevated cartilage turnover in the former disease.