Human transferrin C: the sequence and cystine bridges of the N-terminal region
Brune, J.E.; Martin, S.R.; Boyd, B.S.; Palmour, R.M.; Sutton, H.E.
Texas Reports on Biology and Medicine 36: 47-61
1978
ISSN/ISBN: 0040-4675 PMID: 725796 Document Number: 135175
Human transferrin c (76,000 molecular weight) can be cleaved by cyanogen bromide and separated by gel filtration into 4 fractions, CNBr I, II, III, and IV. CNBr II, the smallest cystine containing fragment, can be separated further into 2 fragments of approximately 3,000 and 9,000 daltons by performic acid oxidation; the smaller fragment is the N-terminus of Tf C. The sequence of both fragments, their relationship to each other through cystine bridges, and their relationship within the whole transferrin molecule is given.
Document emailed within 1 workday
Related Documents
Marcum, J.A.; Thompson, M.A. 1991: The amino-terminal region of a proteochondroitin core protein, secreted by aortic smooth muscle cells, shares sequence homology with the pre-propeptide region of the biglycan core protein from human bone Biochemical and Biophysical Research Communications 175(2): 706-712Francini, G.; Nami, R.; Gonnelli, S.; Groppa, A.; Montagnani, M.; Gennari, C. 1982: Radioimmunoassay for the N-terminal, C-terminal and middle region of human parathyroid hormone in bone diseases Quaderni Sclavo di Diagnostica Clinica E di Laboratorio 18(4): 486-492
Komarova, A.V.; Chufistova, L.S.; Supina, E.V.; Boni, I.V. 2001: Extensive complementarity of the Shine-Dalgarno region and 3'-terminal sequence of 16S ribosomal RNA is inefficient for translation in vivo Bioorganicheskaia Khimiia 27(4): 282-290
Kouzarides, T.; Bankier, A.T.; Barrell, B.G. 1983: Nucleotide sequence of the transforming region of human cytomegalovirus Molecular Biology and Medicine 1(1): 47-58
Tsiomenko, A.B.; Lupashin, V.V.; Morzunov, S.A.; Karpychev, I.V.; El'darov, M.A.; Bezhelarskaia, S.N.; Rubtsov, P.M.; Skriabin, K.G.; Kulaev, I.S. 1990: The nature of N-terminal signal sequence determines the type of intracellular distribution and effectiveness of export of human growth hormone in Saccharomyces cerevisiae Molekuliarnaia Biologiia 24(4): 1126-1133
Bukhman, V.L.; Chumakov, P.M.; Ninkina, N.N.; Glotov, B.O.; Georgiev, G.P. 1988: Exon-intron structure and organization of the 5'-terminal region of the human p53 gene Genetika 24(11): 1909-1917
Xing, H.; Liang, H.; Wan, Z.-Y.; Chen, X.; Wei, M.; Ma, P.-F.; Guan, Q.; Quan, Y.; Hong, K.-X.; Shao, Y.-M. 2004: Distribution of recombinant human immunodeficiency virus type-1 CRF01_AE strains in China and its sequence variations in the env V3-C3 region Zhonghua Yu Fang Yi Xue Za Zhi 38(5): 300-304
Kato, M.; Furuno, A.; Shimizu, N. 1991: Characterization of S1 nuclease-sensitive structure of the pyrimidine/purine biased sequence in promoter region of the human EGF receptor gene Nucleic Acids Symposium Series 25: 35-36
Yasuda, T.; Nadano, D.; Tanaka, Y.; Sawazaki, K.; Kishi, K. 1991: Novel detection method for human protein C inhibitor (PCI) using immunoblotting with antibodies specific to synthetic peptides corresponding to the N-terminal and C-terminal amino acid sequences of human PCi Biochemistry International 25(3): 553-560
Morgan, E.L.; Ember, J.A.; Sanderson, S.D.; Scholz, W.; Buchner, R.; Ye, R.D.; Hugli, T.E. 1993: Anti-C5a receptor antibodies. Characterization of neutralizing antibodies specific for a peptide, C5aR-(9-29), derived from the predicted amino-terminal sequence of the human C5a receptor Journal of Immunology 151(1): 377-388
Guan, Y.; Chen, J.; Shao, Y.; Zhao, Q.; Zeng, Y.; Zhang, J.; Duan, Y.; Kostler, J.; Wolf, H. 1997: Subtype and sequence analysis of the C2-V3 region of gp120 genes among human immunodeficiency virus infected IDUs in Ruili epidemic area of Yunnan Province of China Zhonghua Shi Yan he Lin Chuang Bing du Xue Za Zhi 11(1): 8-12
Gres, A.A.; Nitkin, D.M.; Juraha, T.M.; Sivakow, A.A. 2016: Cystine as a risk factor of the stone formation in kidney: the reference value range of urinary excretion, the stage diagnosis of cystine metabolism disorder Urologiia 2016(4): 10-14
Lu, L.; Bicknell, D.C.; Piacibello, W.; Broxmeyer, H.E. 1986: Purified human transferrin and "transferrin" released from sorted T8+ lymphocytes suppress release of granulocyte-macrophage colony-stimulating factors from sorted T4+ lymphocytes stimulated by phytohemagglutinin Experimental Hematology 14(10): 955-962
Palker, T.J.; Scearce, R.M.; Copeland, T.D.; Oroszlan, S.; Haynes, B.F. 1986: C-terminal region of human T cell lymphotropic virus type i (HTLVI) p19 core protein is immunogenic in humans and contains an HTLVI-specific epitope Journal of Immunology 136(7): 2393-2397
Schaffer, A.; Cerutti, A.; Shah, S.; Zan, H.; Casali, P. 1999: The evolutionarily conserved sequence upstream of the human Ig heavy chain S gamma 3 region is an inducible promoter: synergistic activation by CD40 ligand and IL-4 via cooperative NF-kappa B and STAT-6 binding sites Journal of Immunology 162(9): 5327-5336
Rupasov, V.V.; Adyshev, D.M.; Morozov, S.M.; Belzhelarskaia, S.N.; Man'kin, A.S. 1984: 3'terminal nucleotide sequence of barley stripe mosaic virus RNA Molekuliarnaia Biologiia 18(1): 140-145
Wong, J.; Applegarth, D.A. 1987: Quantification of pipecolic acid in plasma, and of urinary cystine in the presence of penicillamine-cystine disulfide, with the Beckman 6300 amino acid analyzer Clinical Chemistry 33(7): 1302-1303
Paul, D.; Flouret, G.; Tomita, J.T.; Ranney, K.; Schenck, J.; Anderson, B. 1981: Preparation and specificities of antisera to the amino-terminal sequence of the carcinoembryonic antigen Cancer Research 41(6): 2315-2321
Jackson, K.W.; Tang, J. 1978: The amino-terminal sequence of streptokinase and its functional implications in plasminogen activation Thrombosis Research 13(4): 693-699
Drescher, B.; Möhring, R.; Winkler, J.; Nyakatura, G.; Rosenthal, S. 1985: Partial sequence homology between retroviruses of various species in the C-terminal part of the env gene Folia Biologica 31(2): 93-106