6-Chloro-2 (1-piperazinyl) quinoxaline (CPQ) : action on serotonin-induced behavioral responses and interactions with chloromethamphetamine and dimethyl-meta-tyramine
Lotti, V.J.; Clineschmidt, B.V.; Haubrich, D.; Porter, C.C.
Archives Internationales de Pharmacodynamie et de Therapie 235(1): 103-115
1978
ISSN/ISBN: 0003-9780 PMID: 153735 Document Number: 134159
6-Chloro-2(1-piperazinyl) quinoxaline (CPQ) was examined pharmacologically and biochemically as an inhibitor of the neuronal reuptake of serotonin, dopamine and norepinephrine. The compound was 25-50 times more potent than chlorimipramine in potentiating the head-twitch response to 5-hydroxytryptophan (5-HTP) and in antagonizing p-chloromethamphetamine (PCMA)-induced depletion of brain serotonin in rats. CPQ also potentiated the forepaw clonus produced by 5HTP in rats and antagonized PCMA-induced head twitches. At dose levels 30 times those necessary to significantly affect serotoninergic systems, CPQ was ineffective in antagonizing either tetrabenazine-induced sedation in mice or the depletion of rat brain and heart norepinephrine or brain dopamine produced by 4, alpha-dimethylmeta-tyramine (H77/77). The data indicate that CPQ exhibits a high degree of potency and selectivity in inhibiting the neuronal reuptake of serotonin.