Species differences in blood serum reserves for cholesterol solubilization

Bischoff, F.; Bryson, G.

Research Communications in Chemical Pathology and Pharmacology 21(1): 133-144


ISSN/ISBN: 0034-5164
PMID: 684272
Document Number: 133884
The capacity of male human, rat and guinea pig sera to solubilize cholesterol was measured by in vitro equilibration. Evaporation, adsorption by filter paper and/or cholesterol, and protein denaturation were controlled by measuring serum protein and albumin along with cholesterol contents. The uptake of cholesterol for the above groups was 23.1 .+-. 1.2, 18.9 .+-. 1.8 and 10.7 .+-. 0.8 mg/100 ml, respectively. The percentage increases over initial serum cholesterol were 11.9 .+-. 0.9, 18.7 .+-. 2.0 and 35.1 .+-. 2.7%, respectively. The uptake of cholesterol by serum per se without involvement of releasing or target tissues appears to be an irreversible and protective solubility phenomenon. No cholesterol plates were deposited upon the undissolved solute or precipitated on addition of triglyceride to cholesterol-saturated serum. The omnivorous human and rat had a greater absolute reserve for solubilizing cholesterol, but the herbivorous guinea pig had a greatly enhanced relative (% increase) reserve.

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