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Effect of iprazid on serotonin inactivation by lung tissue

Dubileĭ, P.V.

Farmakologiia i Toksikologiia 41(2): 164-167

1978

ISSN/ISBN: 0014-8318
PMID: 658359
Document Number: 133536
Tests on isolated perfused lungs of albino rats were conducted to study the effect of iprazide (5.10(4) M) on inactivation of serotonin (5-OT) by the pulmonary tissue. Iprazide does not noticeably inhibit the inactivation of 5-OT, but it greatly reduces the activity of pulmonary monoaminoxidase, the consequence of which is accumulation of appreciable amount of 5-OT in the lungs. The 5-OT protected against destruction amasses in the cytoplasm and is not bound with cellular organoids.

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