Inactivated saponin vaccine against salmonellal abortion in sheep
Girginov, G.; Vodas, K.; Bozhilov, B.
Veterinarno-Meditsinski Nauki 15(8): 91-95
1978
ISSN/ISBN: 0324-1068 PMID: 571645 Document Number: 133345
An inactivated saponine vaccine is prepared from five highly immunogenic Salmonella abortus ovis strains, selected by means of a biological test on white rats. Saline was used as a diluent of the vaccine, with the addition of 30 per cent glycerine, 0.012 per cent saponine and 0.1 per cent propiolactone. The optimum immunization dose of 5 cm3 is injected singly subcutaneously behind the elbow, two and a half months after impregnation. The vaccine is applied on infected farms before the disease occurs. The cellular-humoral immunity, which forms 14 days after the injection, lasts 4--5 months and protects the sheep against salmonellosis abortion.